Interleukin 1 receptor antagonist (IL-1RA) polymorphism in women with cervical cancer

Anticancer Res. Mar-Apr 2003;23(2A):1099-102.

Abstract

Background: Several studies suggest that immunological components play a key role in the development of cervical cancer. Polymorphism in the IL-1 RA gene was associated with various malignant diseases. Data is lacking for cervical cancer.

Materials and methods: In a prospective study we analysed the polymorphism of IL-1RA in 113 women with cervical cancer and 107 with benign diseases. Genomic DNA fragments were amplified by PCR.

Results: The distribution of genotype frequencies was different between the study and control group with respect to allele 2 heterozygotes (24.8% vs. 13.1%; p = 0.04) but not in the frequencies of allele 1/3 and homozygous allele 2. There were no differences between IL-1 RA 1/2 polymorphism and all other alleles in tumour stage, grading, recurrence status and age.

Conclusion: This data supports the role for allele 2 of the gene encoding for IL1-RA as a genetic determinant of cervical cancer.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / pathology
  • Female
  • Gene Frequency
  • Genetic Carrier Screening
  • Genotype
  • Humans
  • Interleukin 1 Receptor Antagonist Protein
  • Keratins / analysis
  • Middle Aged
  • Neoplasm Staging
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Prospective Studies
  • Sialoglycoproteins / genetics*
  • Uterine Cervical Diseases / genetics
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / pathology

Substances

  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Sialoglycoproteins
  • Keratins