In Vitro Susceptibilities of Malassezia Species to a New Triazole, Albaconazole (UR-9825), and Other Antifungal Compounds

Antimicrob Agents Chemother. 2003 Jul;47(7):2342-4. doi: 10.1128/aac.47.7.2342-2344.2003.

Abstract

The in vitro activity of the new triazole albaconazole (UR-9825) in comparison with those of flucytosine, fluconazole, ketoconazole, itraconazole, and voriconazole against 70 strains of Malassezia spp. was determined by a microdilution method using a colorimetric indicator for metabolic activity. Albaconazole showed an in vitro profile similar to those of the different antifungals tested (MIC <or= 0.06 microg/ml for all the strains).

MeSH terms

  • Antifungal Agents / pharmacology*
  • Drug Resistance, Fungal
  • Fluconazole / pharmacology
  • Flucytosine / pharmacology
  • In Vitro Techniques
  • Itraconazole / pharmacology
  • Ketoconazole / pharmacology
  • Malassezia / drug effects*
  • Microbial Sensitivity Tests
  • Pyrimidines / pharmacology
  • Quinazolines / pharmacology*
  • Triazoles / pharmacology*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Quinazolines
  • Triazoles
  • Itraconazole
  • Fluconazole
  • Flucytosine
  • Voriconazole
  • Ketoconazole
  • albaconazole