Risk factors for choroidal neovascularization and vision loss in the fellow eye study of CNVPT

Retina. 2003 Jun;23(3):307-14. doi: 10.1097/00006982-200306000-00004.


Purpose: To identify risk factors for the development of choroidal neovascularization (CNV) and vision loss in the Fellow Eye Study of the Choroidal Neovascularization Prevention Trial.

Methods: Retrospective review of 121 patients enrolled in a multicentered, randomized, controlled trial. Patients had neovascular age-related macular degeneration in one eye and more than 10 large drusen in the other eye. Records of patients randomly assigned to laser treatment or observation were reviewed through 4 years of follow-up. Three candidate risk factors for the development of CNV and vision loss were evaluated.

Results: Eyes with hyperfluorescent drusen on fluorescein angiography at 3 minutes appeared to have a decreased risk of CNV. Patchy choroidal filling was seen in 14% of patients. Eyes with patchy choroidal perfusion showed a higher risk of developing CNV that was not statistically significant, and the increased risk was present only in treated eyes. Reticular pseudodrusen were present in only three eyes.

Conclusions: Reticular pseudodrusen were rare. Late drusen fluorescence may protect against the development of CNV.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Blindness / etiology*
  • Blindness / prevention & control
  • Choroidal Neovascularization / etiology*
  • Choroidal Neovascularization / prevention & control
  • Female
  • Fluorescein Angiography
  • Follow-Up Studies
  • Humans
  • Laser Coagulation
  • Macular Degeneration / complications*
  • Macular Degeneration / prevention & control
  • Male
  • Middle Aged
  • Retinal Drusen / complications*
  • Retinal Drusen / prevention & control
  • Retrospective Studies
  • Risk Factors
  • Visual Acuity