Association of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma: a case-control study in Chinese population

Cancer Sci. 2003 May;94(5):448-52. doi: 10.1111/j.1349-7006.2003.tb01463.x.


A case-control study of 164 lung adenocarcinoma (AC) patients with 181 age- and gender-matched healthy controls was conducted in order to assess any associations between glutathione-S-transferase M1 (GSTM1), cytochrome P4501A1 (CYP1A1) and cytochrome P4502E1 (CYP2E1) polymorphisms and susceptibility to lung AC in Chinese. The presence of CYP2E1 variant allele was significantly less frequent in cases than in controls, while the distribution of GSTM1 null genotype and variant CYP1A1 Msp1 allele did not vary between cases and controls. After adjustment for age, gender, smoking and all other genotypes, the CYP2E1 Rsa1 variant allele was significantly associated with decreased risk of lung AC [odds ratio 0.534 (95% confidence interval, 0.340-0.837)]. Furthermore, 3.0-fold increased risk was found in individuals with combined GSTM1 null genotype and CYP2E1 Rsa1 wild type versus those with combined GSTM1 non-null type and CYP2E1 variant allele. Our results suggest that CYP2E1 Rsa1 variant allele is associated with a decreased risk of lung AC, and combined GSTM1 null genotype and CYP2E1 Rsa1 wild type has a promoting effect on susceptibility to lung AC.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / epidemiology
  • Adenocarcinoma / genetics*
  • Adult
  • Age Distribution
  • Aged
  • Case-Control Studies
  • China
  • Cytochrome P-450 CYP1A1 / genetics*
  • Cytochrome P-450 CYP2E1 / genetics*
  • DNA Restriction Enzymes
  • Female
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Glutathione Transferase / genetics*
  • Humans
  • Lung Neoplasms / epidemiology
  • Lung Neoplasms / genetics*
  • Male
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Genetic / genetics*
  • Sex Distribution
  • Smoking


  • Cytochrome P-450 CYP2E1
  • Cytochrome P-450 CYP1A1
  • Glutathione Transferase
  • glutathione S-transferase M1
  • DNA Restriction Enzymes