hnRNP A2/B1 binds specifically to single stranded vertebrate telomeric repeat TTAGGGn

Nucleic Acids Res. 1992 Dec 25;20(24):6461-4. doi: 10.1093/nar/20.24.6461.


We have previously isolated a protein from mouse liver nuclei that specifically binds to single stranded (TTAGGG)n repeats. TTAGGG is the telomeric repeats of mammals and we therefore named the new protein single stranded telomere binding protein (sTBP). Further studies now identify sTBP as heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 on the basis of amino acid sequence determination and antibody reactivity. A2 and B1 form a major part of the protein component of hnRNP particles and are abundant nuclear proteins. Unexpectedly, A2/B1 has a high specificity for binding to the RNA equivalent of TTAGGG, UUAGGG, but under the same conditions does not appear to have a strong affinity for a number of other RNA species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Base Sequence
  • Binding Sites
  • Binding, Competitive
  • DNA / metabolism
  • DNA-Binding Proteins / metabolism*
  • Heterogeneous-Nuclear Ribonucleoprotein Group A-B
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Immunoblotting
  • Liver / metabolism*
  • Mice
  • Molecular Sequence Data
  • Nuclear Proteins / isolation & purification
  • Nuclear Proteins / metabolism
  • Oligodeoxyribonucleotides
  • Plasmids
  • RNA / metabolism
  • RNA-Binding Proteins / metabolism
  • Repetitive Sequences, Nucleic Acid*
  • Ribonucleoproteins / immunology
  • Ribonucleoproteins / isolation & purification
  • Ribonucleoproteins / metabolism*
  • Vertebrates


  • Antibodies, Monoclonal
  • DNA-Binding Proteins
  • Heterogeneous-Nuclear Ribonucleoprotein Group A-B
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Nuclear Proteins
  • Oligodeoxyribonucleotides
  • RNA-Binding Proteins
  • Ribonucleoproteins
  • hnRNP A2
  • RNA
  • DNA