This article reviews current literature regarding antifungal drugs available for veterinary and human use and those that are in clinical trials. Drugs include the polyenes, amphotericin B and nystatin; flucytosine; and the first generation triazoles. Antifungal agents generally not used in avian medicine or which are being analyzed in clinical trials in people include lipid formulations of amphotericin B and nystatin, voriconazole, echinocandins, and the allylamines. Information about the pharmacology of the triazoles in people is contrasted with known information for these drugs in birds. Extrapolation of efficacy to avian species also is discussed.