Age-related changes in galanin- and calretinin-immunoreactive nerves of guinea-pig gallbladder

Neuroreport. 1992 Nov;3(11):990-2. doi: 10.1097/00001756-199211000-00011.


Age-related changes in the expression of galanin- and calretinin-like immunoreactivity in the ganglionated plexus of 2-4 day, 6 month and 2 year old guinea-pig gallbladder were investigated. The ganglionated plexus was studied using immunohistochemical labelling techniques on whole mount stretch preparations of the gallbladders. Galanin- and calretinin-like immunoreactivity did not differ significantly between age groups of the 2-4 day and 6 month olds except for some reduction of calretinin-immunofluorescent nerves in the 6 month old preparations. However, in the ganglionated plexus of the 2 year old guinea-pig gallbladders, neither galanin- nor calretinin-like immunoreactivity could be detected. The implication of these findings, in relation to the physiological activity of the gallbladder is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / metabolism*
  • Animals
  • Calbindin 2
  • Galanin
  • Gallbladder / innervation*
  • Gallbladder / metabolism
  • Guinea Pigs
  • Immunohistochemistry
  • Male
  • Peptides / immunology
  • Peptides / metabolism*
  • S100 Calcium Binding Protein G / immunology
  • S100 Calcium Binding Protein G / metabolism*


  • Calbindin 2
  • Peptides
  • S100 Calcium Binding Protein G
  • Galanin