Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling

FEBS Lett. 2003 Jul 3;546(1):32-6. doi: 10.1016/s0014-5793(03)00438-1.


The insulin receptor substrate (IRS) proteins act as important mediators of insulin action. Their regulation serves to augment the specificity of the insulin signalling cascade. They can be regulated--both positively and negatively--at the level of phosphorylation, and signalling through these proteins can be further modulated through the actions of SOCS (suppressor of cytokine signalling) proteins. Understanding the mechanisms of IRS regulation will provide further insight into the pathophysiology of insulin resistance and type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytokines / metabolism
  • Diabetes Mellitus, Type 2 / metabolism
  • Humans
  • Insulin / metabolism*
  • Insulin Resistance
  • Models, Biological
  • Phosphorylation
  • Proteins / metabolism*
  • Receptor, Insulin / metabolism*
  • Repressor Proteins / metabolism
  • Signal Transduction*


  • Cytokines
  • Insulin
  • Proteins
  • Repressor Proteins
  • Receptor, Insulin