MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation

FEBS Lett. 2003 Jul 3;546(1):51-8. doi: 10.1016/s0014-5793(03)00451-4.


That signalling pathways, particularly the mitogen-activated protein kinase cascades, elicit modification of chromatin proteins such as histone H3 by phosphorylation and/or acetylation concomitant with gene activation is now well established. The picture that is emerging is one of a complex and dynamic pattern of multiple modifications at the H3 tail. Here, we review the inducible gene systems where H3 modifications have been reported and re-evaluate the controversy as to the kinase(s) that phosphorylates it as well as the proposed coupling between H3 phosphorylation and acetylation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylation
  • Animals
  • Gene Expression Regulation
  • Genes, Immediate-Early
  • Histones / chemistry
  • Histones / metabolism*
  • Humans
  • MAP Kinase Signaling System
  • Mitogen-Activated Protein Kinases / metabolism*
  • Phosphorylation
  • Signal Transduction
  • Trans-Activators / metabolism
  • Transcriptional Activation


  • Histones
  • Trans-Activators
  • Mitogen-Activated Protein Kinases