Protein kinase D: a family affair

FEBS Lett. 2003 Jul 3;546(1):81-6. doi: 10.1016/s0014-5793(03)00487-3.


The protein kinase D family of enzymes consists of three isoforms: PKD1/PKCmu PKD2 and PKD3/PKCnu. They all share a similar architecture with regulatory sub-domains that play specific roles in the activation, translocation and function of the enzymes. The PKD enzymes have recently been implicated in very diverse cellular functions, including Golgi organization and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Biological Transport
  • Cell Division
  • Cell Membrane / metabolism
  • Enzyme Activation
  • Golgi Apparatus / metabolism
  • Humans
  • Isoenzymes / chemistry
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Models, Biological
  • Protein Kinase C* / chemistry
  • Protein Kinase C* / genetics
  • Protein Kinase C* / metabolism
  • Signal Transduction
  • Structure-Activity Relationship
  • Substrate Specificity


  • Isoenzymes
  • protein kinase D
  • Protein Kinase C