Search for new cyclic AMP-binding proteins

FEBS Lett. 2003 Jul 3;546(1):103-7. doi: 10.1016/s0014-5793(03)00561-1.


Today, there is evidence that the cAMP-dependent kinases (PKA) are not the only intracellular receptors involved in intracellular cAMP signalling in eukaryotes. Other cAMP-binding proteins have been recently identified, including some cyclic nucleotide-gated channels and Epac (exchange protein directly activated by cAMP) proteins. All these proteins bind cAMP through conserved cyclic nucleotide monophosphate-binding domains. However, all putative cAMP-binding proteins having such domains, as revealed by computer analysis, do not necessarily bind cAMP, indicating that their presence is not a sufficient criteria to predict cAMP-binding property for a protein.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Consensus Sequence
  • Cyclic AMP / metabolism*
  • Cyclic AMP Receptor Protein / metabolism
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Humans
  • Ion Channel Gating
  • Molecular Sequence Data
  • Protein Structure, Secondary
  • Sequence Homology, Amino Acid
  • Signal Transduction


  • Cyclic AMP Receptor Protein
  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases