New intracellular components of bone morphogenetic protein/Smad signaling cascades

FEBS Lett. 2003 Jul 3;546(1):133-9. doi: 10.1016/s0014-5793(03)00566-0.


Bone morphogenetic proteins (BMPs) regulate many processes in the embryo, including cell type specification, patterning, apoptosis, and epithelial-mesenchymal interaction. They also act in soft and hard tissues in adult life. Their signals are transduced from the plasma membrane to the nucleus through a limited number of Smad proteins. The list of Smad-interacting proteins is however growing and it is clear that these partners determine the outcome of the signal. We summarize the present status in BMP/Smad signaling, with emphasis on recently identified Smad partners and how these proteins may cooperate in the regulation of the expression of BMP target genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Body Patterning
  • Bone Morphogenetic Proteins / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Embryo, Mammalian
  • Epithelium
  • Humans
  • Mesoderm
  • Models, Biological
  • Signal Transduction*
  • Smad Proteins
  • Trans-Activators / metabolism*
  • Transforming Growth Factor beta / metabolism


  • Bone Morphogenetic Proteins
  • DNA-Binding Proteins
  • Smad Proteins
  • Trans-Activators
  • Transforming Growth Factor beta