Folate deficiency, biopterin and monoamine metabolism in depression

Psychol Med. 1992 Nov;22(4):871-6. doi: 10.1017/s0033291700038447.

Abstract

Seven (21%) of 34 patients with a severe DSM-III diagnosis of major depression had red-cell folate levels below 150 ng/ml. This subgroup with folate deficiency had significantly lower CSF 5-hydroxyindoleacetic acid (5HIAA) compared to neurological controls. For all depressed patients red-cell folate was significantly correlated with CSF 5HIAA and homovanillic acid (HVA). CSF tetrahydrobiopterin (BH4) was significantly correlated with CSF 5HIAA and HVA and red-cell folate. Our observations provide further evidence of the links between folate, biopterin and monoamine metabolism in depression.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Biogenic Monoamines / analysis*
  • Biogenic Monoamines / blood
  • Biogenic Monoamines / metabolism
  • Biopterin / deficiency*
  • Cerebrospinal Fluid / chemistry
  • Depressive Disorder / classification
  • Depressive Disorder / diagnosis
  • Depressive Disorder / metabolism*
  • Female
  • Homovanillic Acid / analysis
  • Humans
  • Hydroxyindoleacetic Acid / analysis
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales
  • Pteroylpolyglutamic Acids / analysis*
  • Pteroylpolyglutamic Acids / blood
  • Pteroylpolyglutamic Acids / metabolism

Substances

  • Biogenic Monoamines
  • Pteroylpolyglutamic Acids
  • Biopterin
  • Hydroxyindoleacetic Acid
  • Homovanillic Acid