Conserved microtubule-actin interactions in cell movement and morphogenesis

Nat Cell Biol. 2003 Jul;5(7):599-609. doi: 10.1038/ncb0703-599.


Interactions between microtubules and actin are a basic phenomenon that underlies many fundamental processes in which dynamic cellular asymmetries need to be established and maintained. These are processes as diverse as cell motility, neuronal pathfinding, cellular wound healing, cell division and cortical flow. Microtubules and actin exhibit two mechanistic classes of interactions--regulatory and structural. These interactions comprise at least three conserved 'mechanochemical activity modules' that perform similar roles in these diverse cell functions.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Animals
  • Cell Differentiation / physiology*
  • Cell Division / physiology
  • Cell Movement / physiology*
  • Contractile Proteins / metabolism
  • Eukaryotic Cells / metabolism*
  • Eukaryotic Cells / ultrastructure
  • Growth Cones / metabolism
  • Growth Cones / ultrastructure
  • Humans
  • Microtubules / metabolism*
  • Wound Healing / physiology


  • Contractile Proteins