Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development

Mech Dev. 1992 Nov;39(1-2):29-39. doi: 10.1016/0925-4773(92)90023-d.


The murine paired-box-containing gene 5, Pax-5, is highly homologous to two other Pax genes, Pax-2 and Pax-8. The expression pattern of Pax-5 during mouse embryogenesis was examined by in situ RNA hybridization and compared to those of Pax-2 and Pax-8. Beginning at day 9.5 postcoitum (p.c.), Pax-5 was expressed in the developing brain, predominantly at the midbrain-hindbrain boundary, and in the neural tube. While the neural tube expression pattern overlapped completely with Pax-2 and Pax-8, the expression pattern in the brain was only partially overlapping. Unlike Pax-2 and Pax-8, Pax-5 was not expressed in the developing excretory system, thyroid, eye or ear. Our data suggest that Pax-5 has a role in the development of the central nervous system.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / embryology*
  • DNA-Binding Proteins / biosynthesis*
  • DNA-Binding Proteins / genetics
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics
  • Embryonic and Fetal Development / genetics*
  • Female
  • Gene Expression Regulation*
  • Genes*
  • In Situ Hybridization
  • Male
  • Mice / embryology*
  • Mice / genetics
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Nerve Tissue Proteins / biosynthesis*
  • Nerve Tissue Proteins / genetics
  • Nuclear Proteins / biosynthesis*
  • Nuclear Proteins / genetics
  • PAX5 Transcription Factor
  • RNA / analysis
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Transcription Factors*
  • Zebrafish / embryology
  • Zebrafish / genetics


  • DNA-Binding Proteins
  • Nerve Tissue Proteins
  • Nuclear Proteins
  • PAX5 Transcription Factor
  • Pax5 protein, mouse
  • Transcription Factors
  • RNA