Abstract
The murine paired-box-containing gene 5, Pax-5, is highly homologous to two other Pax genes, Pax-2 and Pax-8. The expression pattern of Pax-5 during mouse embryogenesis was examined by in situ RNA hybridization and compared to those of Pax-2 and Pax-8. Beginning at day 9.5 postcoitum (p.c.), Pax-5 was expressed in the developing brain, predominantly at the midbrain-hindbrain boundary, and in the neural tube. While the neural tube expression pattern overlapped completely with Pax-2 and Pax-8, the expression pattern in the brain was only partially overlapping. Unlike Pax-2 and Pax-8, Pax-5 was not expressed in the developing excretory system, thyroid, eye or ear. Our data suggest that Pax-5 has a role in the development of the central nervous system.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Brain / embryology*
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DNA-Binding Proteins / biosynthesis*
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DNA-Binding Proteins / genetics
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Drosophila melanogaster / embryology
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Drosophila melanogaster / genetics
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Embryonic and Fetal Development / genetics*
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Female
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Gene Expression Regulation*
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Genes*
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In Situ Hybridization
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Male
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Mice / embryology*
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Mice / genetics
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Mice, Inbred C57BL
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Molecular Sequence Data
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Nerve Tissue Proteins / biosynthesis*
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Nerve Tissue Proteins / genetics
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Nuclear Proteins / biosynthesis*
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Nuclear Proteins / genetics
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PAX5 Transcription Factor
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RNA / analysis
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Sequence Alignment
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Sequence Homology, Amino Acid
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Species Specificity
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Transcription Factors*
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Zebrafish / embryology
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Zebrafish / genetics
Substances
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DNA-Binding Proteins
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Nerve Tissue Proteins
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Nuclear Proteins
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PAX5 Transcription Factor
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Pax5 protein, mouse
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Transcription Factors
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RNA