Retention of dye after indocyanine Green-assisted internal limiting membrane peeling

Am J Ophthalmol. 2003 Jul;136(1):172-4. doi: 10.1016/s0002-9394(03)00074-6.


Purpose: To describe the long-term retention of indocyanine green (ICG) in the fundus after ICG-assisted internal limiting membrane peeling.

Design: Case report. Two patients underwent vitrectomy including ICG-assisted internal limiting membrane peeling. The fundus was examined with a 780-nm infrared illumination of a scanning laser ophthalmoscope after surgery.

Results: No ICG staining of the fundus was visible ophthalmoscopically. Examination with a scanning laser ophthalmoscope, however, detected fluorescence from residual ICG until 6 months after surgery in case 1 and 9 months in case 2. No complication related to the residual ICG was observed.

Conclusions: The results suggested that ICG remains in the fundus for a long period after surgery. Clearance of the dye from the diabetic retina may be prolonged.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Coloring Agents / pharmacokinetics*
  • Epiretinal Membrane / diagnosis
  • Epiretinal Membrane / surgery*
  • Female
  • Fluorescence
  • Humans
  • Indocyanine Green / pharmacokinetics*
  • Lasers
  • Male
  • Middle Aged
  • Ophthalmoscopy
  • Retina / metabolism*
  • Retinal Perforations / surgery
  • Vitrectomy


  • Coloring Agents
  • Indocyanine Green