Molecular mechanisms of glioma invasiveness: the role of proteases

Nat Rev Cancer. 2003 Jul;3(7):489-501. doi: 10.1038/nrc1121.


The invasive nature of brain-tumour cells makes an important contribution to the ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably infiltrate the surrounding normal brain tissue, which leads to tumour recurrence. Such local invasion remains an important cause of mortality and underscores the need to understand in more detail the mechanisms of tumour invasiveness. Several proteases influence the malignant characteristics of gliomas--could their inhibition prove to be a useful therapeutic strategy?

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cathepsin B / metabolism
  • Central Nervous System Neoplasms / metabolism*
  • Central Nervous System Neoplasms / pathology*
  • Central Nervous System Neoplasms / physiopathology
  • Endopeptidases / physiology*
  • Glioma / metabolism*
  • Glioma / pathology*
  • Glioma / physiopathology
  • Humans
  • Matrix Metalloproteinases / metabolism
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local / metabolism
  • Plasminogen Activators / metabolism
  • Receptors, Cell Surface / metabolism
  • Receptors, Urokinase Plasminogen Activator
  • Urokinase-Type Plasminogen Activator / metabolism


  • PLAUR protein, human
  • Receptors, Cell Surface
  • Receptors, Urokinase Plasminogen Activator
  • Endopeptidases
  • Plasminogen Activators
  • Urokinase-Type Plasminogen Activator
  • Cathepsin B
  • Matrix Metalloproteinases