Curing metastatic cancer: lessons from testicular germ-cell tumours

Nat Rev Cancer. 2003 Jul;3(7):517-25. doi: 10.1038/nrc1120.


Most metastatic cancers are fatal. More than 80% of patients with metastatic testicular germ-cell tumours (TGCTs), however, can be cured using cisplatin-based combination chemotherapy. Why are TGCTs more sensitive to chemotherapeutics than most other tumour types? Answers to this question could lead to new treatments for metastatic cancers.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Cisplatin / therapeutic use
  • Humans
  • Male
  • Neoplasm Metastasis / physiopathology*
  • Neoplasm Metastasis / therapy*
  • Neoplasms, Germ Cell and Embryonal / drug therapy*
  • Testicular Neoplasms / drug therapy*


  • Antineoplastic Agents
  • Cisplatin