HIV-1 pathogenesis

Nat Med. 2003 Jul;9(7):853-60. doi: 10.1038/nm0703-853.


Despite considerable advances in HIV science in the past 20 years, the reason why HIV-1 infection is pathogenic is still debated and the goal of eradicating HIV-1 infection remains elusive. A deeper understanding of the interplay between HIV-1 and its host and why simian immunodeficiency virus (SIV) is nonpathogenic in some natural hosts may provide a few answers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / virology*
  • Dendritic Cells / virology
  • HIV Infections / pathology
  • HIV Infections / virology
  • HIV-1 / pathogenicity*
  • HIV-1 / physiology
  • Host-Parasite Interactions
  • Humans
  • Macrophages / virology
  • Simian Immunodeficiency Virus / pathogenicity
  • Virus Replication / physiology*