Syntheses of two neuromedin U (NMU) analogues and their comparative reducing food intake effect in rats

Amino Acids. 2003 Jul;25(1):107-10. doi: 10.1007/s00726-002-0351-3.


To examine the roles of aromatic rings Tyr residues at positions 1 and 6 and Phe residues at positions 16, 17 and 19 of rat neuromedin U-23 (NMU-23) (Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-Gly-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH(2)) for reducing food intake activity in male Wistar rats, two NMU-23 analogues, [Phe(4F)(16,17,19)]NMU-23 and [Tyr(Me)(1,6)]NMU-23, were synthesized by Fmoc strategy of manual solid-phase method. The synthetic NMU-23 showed reducing effect on food intake in rats. [Phe(4F)(16,17,19)]NMU-23 exhibited higher reducing food intake effect than that of NMU-23. On the contrary, [Tyr(Me)(1,6)]NMU-23 showed no reducing effect on food intake in rats than that of NMU-23.

MeSH terms

  • Amino Acids / chemistry
  • Amino Acids / metabolism
  • Animals
  • Eating*
  • Male
  • Neuropeptides / chemistry*
  • Neuropeptides / metabolism*
  • Peptides / administration & dosage
  • Peptides / chemistry
  • Peptides / metabolism
  • Rats
  • Rats, Wistar


  • Amino Acids
  • Neuropeptides
  • Peptides
  • neuromedin U