[Cell cycle and checkpoints in oncology: new therapeutic targets]

Med Sci (Paris). 2003 Feb;19(2):173-86. doi: 10.1051/medsci/2003192173.
[Article in French]


Leland H. Hartwell, Paul M. Nurse et R. Timothy Hunt just received the Nobel price for their discovery of the molecular components of the cell cycle and cell cycle checkpoints. This review is an update of the molecular networks driving the cell cycle and its regulation, and of the importance of this knowledge for understanding the mechanisms driving oncogenesis and therapeutic developments.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / pharmacology*
  • Cell Cycle Proteins / therapeutic use*
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / physiopathology


  • Antineoplastic Agents
  • Cell Cycle Proteins