Calcium Signalling: Dynamics, Homeostasis and Remodelling

Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29. doi: 10.1038/nrm1155.

Abstract

Ca2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. An extensive Ca2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics. Rapid highly localized Ca2+ spikes regulate fast responses, whereas slower responses are controlled by repetitive global Ca2+ transients or intracellular Ca2+ waves. Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / physiology*
  • Calcium Channels / metabolism
  • Calcium Signaling / physiology*
  • Homeostasis / physiology*
  • Humans
  • Models, Biological
  • Second Messenger Systems / physiology*

Substances

  • Calcium Channels
  • Calcium