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. 2003 Jul;4(7):552-65.
doi: 10.1038/nrm1150.

Regulation of Cell Death: The Calcium-Apoptosis Link


Regulation of Cell Death: The Calcium-Apoptosis Link

Sten Orrenius et al. Nat Rev Mol Cell Biol. .


To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living organisms--survival factor or ruthless killer. It has long been known that Ca2+ signals govern a host of vital cell functions and so are necessary for cell survival. However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death.

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