Human and mouse proteases: a comparative genomic approach

Nat Rev Genet. 2003 Jul;4(7):544-58. doi: 10.1038/nrg1111.


The availability of the human and mouse genome sequences has allowed the identification and comparison of their respective degradomes--the complete repertoire of proteases that are produced by these organisms. Because of the essential roles of proteolytic enzymes in the control of cell behaviour, survival and death, degradome analysis provides a useful framework for the global exploration of these protease-mediated functions in normal and pathological conditions.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Computational Biology
  • Databases, Factual*
  • Endopeptidases / chemistry
  • Endopeptidases / genetics*
  • Endopeptidases / metabolism
  • Genome*
  • Humans
  • Models, Genetic


  • Endopeptidases