[Nucleotide sequences of long terminal repeats of the human endogenous retrovirus (LTR HERV-K) on the short arm of chromosome 7: identification, analysis and evaluation of transcriptional activity]

Genetika. 2003 May;39(5):702-8.
[Article in Russian]

Abstract

Six clones containing long terminal repeat (LTR) sequences of human endogenous retrovirus of the HERV-K family were found in the YAC library (1200 kb) of the short arm of human chromosome 7. The sequence sizes of the three clones corresponded to the full-length LTR (969 bp). The LTR localization was determined using FISH and verified by comparison with the GenBank database. All three DNA fragments containing solitary LTRs were transcribed in normal germline cells (testicular parenchyma tissue). The differences in the expression of these clones in the germline tumor cells (seminoma) were observed.

Publication types

  • English Abstract

MeSH terms

  • Base Sequence
  • Chromosomes, Human, Pair 7 / genetics*
  • DNA, Viral / analysis
  • Endogenous Retroviruses / genetics*
  • Gene Expression
  • Gene Library
  • Humans
  • Male
  • Seminoma / metabolism
  • Sequence Analysis, RNA
  • Sequence Homology, Nucleic Acid
  • Terminal Repeat Sequences
  • Testis / metabolism
  • Transcription, Genetic*

Substances

  • DNA, Viral