Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases

Nucleic Acids Symp Ser. 1992;(27):191-2.

Abstract

Some sugar modified analogs of 2'-deoxy-E-5-styryluridine triphosphates were synthesized and examined for their inhibitory effects on eukaryotic DNA polymerases and HIV-1 reverse transcriptase. Among these compounds, 3'-azido-2',3'-dideoxy-E-5-styrylUTP (6) and 2',3'-dideoxy-E-5-styrylUTP (7) showed remarkable inhibitory effects on reverse transcriptase. The mode of action and the influence of the substituent at C-5 of 2',3'-dideoxyUTP analogs will be described.

MeSH terms

  • Eukaryotic Cells / enzymology
  • HIV Reverse Transcriptase
  • Nucleic Acid Synthesis Inhibitors*
  • Reverse Transcriptase Inhibitors*
  • Styrenes / pharmacology*
  • Uridine Triphosphate / analogs & derivatives*
  • Uridine Triphosphate / pharmacology

Substances

  • Nucleic Acid Synthesis Inhibitors
  • Reverse Transcriptase Inhibitors
  • Styrenes
  • HIV Reverse Transcriptase
  • Uridine Triphosphate