An unexpected and severe neurological disorder with permanent disability acquired during short-course treatment with metronidazole

Scand J Infect Dis. 2003;35(4):279-80. doi: 10.1080/00365540310005314.


A case is reported of permanent sensorimotor distal polyneuropathy combined with sensory hemisymptoms in a middle-aged woman after only 10 g of metronidazole given as 400 mg, three times daily for 9 d. The disability is still permanent after 22 months of observation. No other cause has been found.

Publication types

  • Case Reports

MeSH terms

  • Chronic Disease
  • Disability Evaluation
  • Female
  • Follow-Up Studies
  • Humans
  • Metronidazole / adverse effects*
  • Metronidazole / therapeutic use
  • Middle Aged
  • Nervous System Diseases / chemically induced
  • Nervous System Diseases / physiopathology
  • Peripheral Nervous System Diseases / chemically induced*
  • Peripheral Nervous System Diseases / physiopathology
  • Risk Assessment
  • Severity of Illness Index


  • Metronidazole