Correlation of serotonin and monoamine oxidase levels with anxiety level in diarrhea-predominant irritable bowel syndrome

Indian J Gastroenterol. May-Jun 2003;22(3):88-90.

Abstract

Background: Irritable bowel syndrome (IBS) is generally considered to have a psychogenic component in its physiopathology.

Aim: To study the role of serotonin (5-hydroxytryptamine; 5-HT), monoamine oxidase (MAO) and anxiety, and to elucidate the relationship between these in patients with diarrhea-predominant IBS.

Methods: 5-HT and MAO activity and anxiety levels were studied in 20 healthy volunteers (aged 18-25 years; all men) and 57 patients with diarrhea-predominant IBS (30-60 years; all men).

Results: The concentrations of 5-HT (0.3 [0.04] microg/ mL) and MAO (15.5 [3.2] U/mL), and the anxiety level score (14.4 [2.9]) were significantly higher (p < 0.001) in patients than in healthy volunteers (0.1 [0.02], 6.4 [1.4] and 3.4 [1.2], respectively). These parameters correlated with each other in both patients and volunteers.

Conclusions: Elevated 5-HT and MAO activity and anxiety may play a role in patients with diarrhea-predominant IBS.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Anxiety / metabolism*
  • Biomarkers / blood
  • Colonic Diseases, Functional / complications
  • Colonic Diseases, Functional / metabolism*
  • Diarrhea / complications*
  • Diarrhea / metabolism
  • Humans
  • India
  • Male
  • Middle Aged
  • Monoamine Oxidase / metabolism*
  • Serotonin / metabolism*
  • Statistics as Topic

Substances

  • Biomarkers
  • Serotonin
  • Monoamine Oxidase