Adverse effect of nitrous oxide in a child with 5,10-methylenetetrahydrofolate reductase deficiency

N Engl J Med. 2003 Jul 3;349(1):45-50. doi: 10.1056/NEJMoa021867.
No abstract available

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5,10-Methylenetetrahydrofolate Reductase (FADH2)
  • 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / drug effects*
  • Anesthetics, Inhalation / adverse effects*
  • Cells, Cultured
  • DNA Mutational Analysis
  • Fatal Outcome
  • Fibroblasts / cytology
  • Fibroblasts / enzymology
  • Folic Acid / metabolism
  • Genes, Recessive
  • Homocysteine / metabolism
  • Homocystine / blood
  • Homocystine / urine
  • Humans
  • Hyperhomocysteinemia / etiology
  • Infant
  • Male
  • Metabolism, Inborn Errors / complications
  • Metabolism, Inborn Errors / genetics
  • Metabolism, Inborn Errors / metabolism
  • Methionine / blood
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Nitrous Oxide / adverse effects*
  • Oxidoreductases / deficiency*
  • Oxidoreductases / genetics
  • Oxidoreductases / metabolism
  • Point Mutation*
  • Polymorphism, Genetic
  • RNA / analysis

Substances

  • Anesthetics, Inhalation
  • Homocysteine
  • Homocystine
  • RNA
  • Folic Acid
  • Methionine
  • Oxidoreductases
  • 5,10-Methylenetetrahydrofolate Reductase (FADH2)
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
  • Nitrous Oxide