Prevalence of non-alcoholic steatohepatitis in morbidly obese subjects undergoing gastric bypass

Obes Surg. 2003 Jun;13(3):347-9. doi: 10.1381/096089203765887633.


Background: Obesity is the most common cause of non-alcoholic steatohepatitis (NASH). This is a prospective study to determine the incidence and severity of NASH in patients undergoing Roux-en-Y gastric bypass (RYGBP) for morbid obesity. We also examined the relationship between NASH and potential risk factors.

Methods: In 48 consecutive patients at RYGBP, a core liver biopsy was obtained from the left lateral segment. A single liver pathologist reviewed the histology for steatosis, ballooning/disarray, necroinflammation, and fibrosis.

Results: 84% of patients were female, and average BMI was 51. 18% had WHR >1. The following risk factors were present: DM 16%; hyperlipidemia 61%; HTN 47%; and abnormal LFTs 18%. 90% had abnormal liver histology, and 56% qualified for the diagnosis of NASH. Only DM and abnormal LFTs were found to be significantly related to NASH.

Conclusions: NASH is a common co-morbidity of obesity and requires systemized grading and staging to develop accurate knowledge of the incidence, severity, natural history and impact of weight loss.

Publication types

  • Comparative Study

MeSH terms

  • Age Distribution
  • Anastomosis, Roux-en-Y
  • Biopsy, Needle
  • Comorbidity
  • Fatty Liver / epidemiology*
  • Fatty Liver / pathology*
  • Female
  • Follow-Up Studies
  • Gastric Bypass / methods
  • Humans
  • Immunohistochemistry
  • Male
  • Obesity, Morbid / epidemiology*
  • Obesity, Morbid / surgery*
  • Prevalence
  • Prospective Studies
  • Risk Assessment
  • Sampling Studies
  • Severity of Illness Index
  • Sex Distribution