A simple and highly practical oxidation of primary alcohols to acids mediated by 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)

Chem Pharm Bull (Tokyo). 2003 Jul;51(7):888-9. doi: 10.1248/cpb.51.888.

Abstract

Primary alcohols were quantitatively oxidized in one-pot to acids via 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) mediated oxidation. The reported method is simple and suitable for large scale synthesis.

MeSH terms

  • Acids / metabolism*
  • Alcohols / metabolism*
  • Catalysis / drug effects
  • Cyclic N-Oxides / metabolism*
  • Cyclic N-Oxides / pharmacology
  • Oxidation-Reduction / drug effects
  • Spin Labels
  • Technology, Pharmaceutical / methods*

Substances

  • Acids
  • Alcohols
  • Cyclic N-Oxides
  • Spin Labels
  • TEMPO