A Common 936 C/T Gene Polymorphism of Vascular Endothelial Growth Factor Is Associated With Decreased Breast Cancer Risk

Int J Cancer. 2003 Sep 10;106(4):468-71. doi: 10.1002/ijc.11238.

Abstract

A common 936 C/T polymorphism in the gene for the vascular endothelial growth factor (VEGF) has been associated with VEGF plasma levels. In our case-control study, we investigated the role of this polymorphism for breast cancer risk. VEGF genotype was determined in 500 women with breast cancer and 500 sex- and age-matched healthy control subjects. Carriers of a 936T-allele were more frequent among controls (29.4%) than among patients (17.6%; p = 0.000014). The odds ratio for carriers of a 936T-allele for breast cancer was 0.51 (95% confidence interval 0.38-0.70). Additionally, VEGF plasma levels were determined in 21 nonsmoking post-menopausal controls; carriers of a 936T allele had significantly lower levels (median 23 pg/ml; range 6-50 pg/ml) than noncarriers (37; 21-387; p = 0.034). We conclude that carriers of a VEGF 936T-allele are at decreased risk for breast cancer, this, however, requiring further confirmation in a larger study.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / etiology
  • Breast Neoplasms / genetics*
  • Case-Control Studies
  • DNA Mutational Analysis
  • DNA Primers / chemistry
  • DNA, Neoplasm / genetics
  • Endothelial Growth Factors / blood
  • Endothelial Growth Factors / genetics*
  • Female
  • Gene Expression Regulation, Neoplastic
  • Gene Frequency
  • Genotype
  • Humans
  • Intercellular Signaling Peptides and Proteins / blood
  • Intercellular Signaling Peptides and Proteins / genetics*
  • Lymphokines / blood
  • Lymphokines / genetics*
  • Middle Aged
  • Point Mutation*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics*
  • Risk Factors
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • DNA Primers
  • DNA, Neoplasm
  • Endothelial Growth Factors
  • Intercellular Signaling Peptides and Proteins
  • Lymphokines
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors