Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 194, 8-18

Extrafollicular Antibody Responses


Extrafollicular Antibody Responses

Ian C M MacLennan et al. Immunol Rev.


In adaptive antibody responses, B cells are induced to grow either in follicles where they form germinal centers or in extrafollicular foci as plasmablasts. Extrafollicular growth typically occurs in the medullary cords of lymph nodes and in foci in the red pulp of the spleen. It is not a feature of secondary lymphoid tissue associated with the internal epithelia of the body. All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation.

Similar articles

See all similar articles

Cited by 186 articles

See all "Cited by" articles

Publication types

LinkOut - more resources