Prediction of extrauterine growth retardation (EUGR) in VVLBW infants

J Perinatol. 2003 Jul-Aug;23(5):392-5. doi: 10.1038/


Background: Long-term growth failure in very very low birth weight (VVLBW) infants is a common complication of extreme prematurity. Critical illnesses create challenges to adequate nutriture.

Purpose: To identify predictors of extrauterine growth retardation (EUGR) in VVLBW infants and to evaluate their nutritional intake and subsequent growth.

Study design: A 4-year retrospective chart review of 221 infants <or=1000 g birth weight and <or=29 weeks gestational age who were admitted within 24 hours of birth, were free of major congenital anomalies and survived at least 7 days. Daily intakes and anthropomorphic data were collected and analyzed. Significant events during hospitalization were documented.

Results: Mean energy and protein intakes during hospitalization did not reach recommendations of 120 kcal/kg/d and 3.0 g/kg/day. In utero growth rates could not be consistently reached or sustained. As expected, BW (as measured by BW percentile score) was highly predictive of EUGR (p<0.001). When the independent effect of other predictors of EUGR was considered, only days of total parenteral nutrition (p<0.001) and HC percentile at return to birth weight (p<0.001) made a significant contribution to the prediction of EUGR, once the effect of BW was taken into account.

MeSH terms

  • Child, Preschool
  • Developmental Disabilities / epidemiology*
  • Female
  • Follow-Up Studies
  • Gestational Age
  • Growth Disorders / diagnosis
  • Growth Disorders / epidemiology*
  • Humans
  • Incidence
  • Infant
  • Infant Mortality*
  • Infant Nutritional Physiological Phenomena*
  • Infant, Newborn
  • Infant, Premature
  • Infant, Very Low Birth Weight*
  • Intensive Care Units, Neonatal
  • Logistic Models
  • Male
  • Nutritional Requirements
  • Predictive Value of Tests
  • Probability
  • ROC Curve
  • Retrospective Studies
  • Risk Assessment