Chemoprevention of cancerogenesis--the role of sulforaphane

Acta Pol Pharm. Jan-Feb 2003;60(1):97-100.

Abstract

Isothiocyanates are a group of naturally occurring compounds with interesting medical properties, such as antimicrobial, antioxidant and antitumor activities. In our work we were trying to present the tumoricidal activity of new synthesized derivatives of one isothiocyanate: 1-isothio-cyanato-(4R)-(methylsulfinyl) butane [sulforaphane]. Many chemical substances derived from plants, undoubtedly have protective properties. The effectiveness of sulforaphane is based on induction of hepatic detoxifying enzymes.

MeSH terms

  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Antioxidants / chemistry
  • Glutathione / metabolism
  • Heme Oxygenase (Decyclizing) / metabolism
  • Humans
  • Isothiocyanates
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Neoplasms / prevention & control*
  • Thiocyanates / chemistry
  • Thiocyanates / isolation & purification
  • Thiocyanates / pharmacology*

Substances

  • Anticarcinogenic Agents
  • Antioxidants
  • Isothiocyanates
  • Thiocyanates
  • Heme Oxygenase (Decyclizing)
  • sulforafan
  • Glutathione