Platelet-derived growth factor is angiogenic in vivo

Growth Factors. 1992;7(4):261-6. doi: 10.3109/08977199209046408.

Abstract

PDGF receptors have recently been found to be expressed in microvascular endothelium in vivo under circumstances of endothelial cell activation and angiogenesis suggesting that PDGF may have a direct effect on endothelial cells. We have tested the angiogenic activity of PDGF-AA and -BB homodimers in the chick chorioallantoic membrane in vivo. PDGF-BB was found to consistently induce an angiogenic response whereas PDGF-AA was less active. Morphological analyses revealed that there was little inflammation associated with this response but an increase in vessel density suggested a direct effect of PDGF on embryonic chorioallantoic endothelial cells. In vitro, PDGF-BB was found to be more potent than PDGF-AA in stimulating the chemotaxis of rat brain capillary endothelial cells. This is consistent with a direct effect of PDGF on endothelial cells. Thus, this novel angiogenic activity of PDGF has implications for several developmental and pathological events in which PDGF, particularly the B-chain, is expressed.

Publication types

  • Comparative Study

MeSH terms

  • Allantois / blood supply
  • Animals
  • Brain / blood supply
  • Capillaries / cytology
  • Chemotaxis
  • Chick Embryo
  • Chorion / blood supply
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / physiology
  • Macromolecular Substances
  • Neovascularization, Pathologic*
  • Platelet-Derived Growth Factor / chemistry
  • Platelet-Derived Growth Factor / pharmacology*
  • Rats

Substances

  • Macromolecular Substances
  • Platelet-Derived Growth Factor