Insulin Autoimmunity: prediction/precipitation/prevention Type 1A Diabetes

Autoimmun Rev. 2002 May;1(3):139-45. doi: 10.1016/s1568-9972(02)00035-6.

Abstract

Type 1 diabetes of both the NOD mouse and man is associated with autoimmunity directed against insulin which is the only beta cell specific autoantigen identified to date. One can use autoantibodies to insulin to predict diabetes, use insulin peptides to create insulin autoantibodies, insulitis and diabetes, and use insulin or its peptides in animal models to prevent diabetes. An expanding set of resources are now available for the development and testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin peptides are now underway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Autoantibodies / genetics
  • Autoantibodies / immunology*
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / immunology*
  • Humans
  • Insulin / immunology*
  • Insulin Antibodies / genetics
  • Insulin Antibodies / immunology*
  • Major Histocompatibility Complex / genetics
  • Major Histocompatibility Complex / immunology
  • Mice
  • Mice, Inbred NOD

Substances

  • Autoantibodies
  • Insulin
  • Insulin Antibodies