Structure of the metabotropic glutamate receptor

Curr Opin Neurobiol. 2003 Jun;13(3):271-8. doi: 10.1016/s0959-4388(03)00067-9.


In the twelve years since the molecular elucidation of the metabotropic glutamate receptor subtype 1, a class III family of G-protein-coupled receptors has emerged; members of this family include the calcium-sensing receptor, the GABA(B) receptor, some odorant receptors and some taste receptors. Atomic structures of the ligand-binding core of the original metabotropic glutamate receptor 1 obtained using X-ray crystallography provide a foundation for determining the initial receptor activation of this important family of G-protein-coupled receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Binding Sites / physiology
  • Glutamic Acid / metabolism
  • Humans
  • Models, Molecular
  • Receptors, Metabotropic Glutamate / chemistry*
  • Receptors, Metabotropic Glutamate / metabolism*
  • Structure-Activity Relationship


  • Receptors, Metabotropic Glutamate
  • Glutamic Acid