Regulation of ion channel/neurotransmitter receptor function by RNA editing

Curr Opin Neurobiol. 2003 Jun;13(3):279-83. doi: 10.1016/s0959-4388(03)00062-x.


RNA editing by select adenosine deamination (A-to-I editing) alters functional determinants in certain ion channels and neurotransmitter receptors in vertebrates and invertebrates. In most cases, edited and unedited versions of a given receptor/channel co-exist to expand the functional space of the receptor population. Recent studies have characterized K(+) channels in squid that are edited at multiple positions, revealed a role for Q/R site editing in AMPA receptor assembly, and demonstrated a link between serotonin levels and the extent of editing of a mammalian serotonin receptor.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Ion Channels / chemistry
  • Ion Channels / physiology*
  • RNA Editing / physiology*
  • Receptors, Neurotransmitter / chemistry
  • Receptors, Neurotransmitter / physiology*


  • Ion Channels
  • Receptors, Neurotransmitter