Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization

Brain Res. 2003 Jul 25;979(1-2):245-8. doi: 10.1016/s0006-8993(03)02895-6.

Abstract

Neurotensin is a tridecapeptide that participates in regulation of dopaminergic pathways implicated in nicotine addiction. Previously, we showed that one of our brain-penetrating neurotensin analogs, NT69L, blocks nicotine-induced locomotor sensitization. The present work demonstrates that NT69L blocks both the initiation and the expression of sensitization. In addition chronic NT69L administration blocked the acute effects of nicotine on norepinephrine and serotonin in prefrontal cortex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / metabolism
  • Chromatography, High Pressure Liquid
  • Dopamine / analysis
  • Dopamine / metabolism
  • Ganglionic Stimulants / pharmacology
  • Male
  • Motor Activity / drug effects*
  • Motor Activity / physiology
  • Neurotensin / analogs & derivatives*
  • Neurotensin / pharmacology*
  • Nicotine / pharmacology
  • Norepinephrine / analysis
  • Norepinephrine / metabolism
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin / analysis
  • Serotonin / metabolism
  • Time Factors

Substances

  • Ganglionic Stimulants
  • Peptide Fragments
  • neurotensin 69L
  • Serotonin
  • Neurotensin
  • Nicotine
  • Dopamine
  • Norepinephrine