The effects of tobacco smoke on the homocysteine level--a risk factor of atherosclerosis

Addict Biol. 2003 Jun;8(2):147-58. doi: 10.1080/13556210310001117374.


Homocysteine may promote atherogenesis and thrombogenesis. There is evidence from case - control and cross-sectional cohort studies that there is a positive association between plasma homocysteine levels and coronary artery disease, cerebrovascular disease and peripheral vascular disease. There is also some evidence that certain life-style factors such as cigarette smoking may affect homocysteine levels. In this work is presented a review of recent opinion about the influence of tobacco smoking on homocysteine levels.

Publication types

  • Review

MeSH terms

  • Coronary Artery Disease / etiology*
  • Coronary Artery Disease / physiopathology
  • Folic Acid Deficiency / blood
  • Homocysteine / blood
  • Homocysteine / metabolism*
  • Humans
  • Intracranial Arteriosclerosis / etiology*
  • Intracranial Arteriosclerosis / physiopathology
  • Peripheral Vascular Diseases / etiology
  • Risk Factors
  • Tobacco Use Disorder / complications*
  • Tobacco Use Disorder / metabolism*
  • Vitamin B 12 Deficiency / blood
  • Vitamin B 6 Deficiency / blood


  • Homocysteine