The sodium bile salt cotransport family SLC10

Pflugers Arch. 2004 Feb;447(5):566-70. doi: 10.1007/s00424-003-1130-z. Epub 2003 Jul 8.


The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na(+)/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bile Acids and Salts / metabolism*
  • Biological Transport / physiology
  • Humans
  • Multigene Family / physiology
  • Organic Anion Transporters, Sodium-Dependent / physiology*
  • Sodium / metabolism*
  • Symporters / physiology*


  • Bile Acids and Salts
  • Organic Anion Transporters, Sodium-Dependent
  • Symporters
  • sodium-bile acid cotransporter
  • Sodium