Pathogenesis of Kaposi's sarcoma

Hematol Oncol Clin North Am. 2003 Jun;17(3):717-45. doi: 10.1016/s0889-8588(03)00044-3.


Kaposi's sarcoma (KS) is a disease characterized by proliferative vascular lesions, which almost invariably contain the KS-associated herpesvirus (KSHV), also called human herpesvirus 8. KSHV is a lymphotrophic and angiotrophic herpesvirus, whose genome encodes several proteins involved in proliferation, antiapoptotic functions, and inflammation. Most KS spindle cells express latent KSHV genes, but a few express lytic genes, which might be involved in angiogenic and paracrine mechanisms that contribute to KS pathogenesis. A number of tissue culture and mouse models have been established, but a comprehensive system that accurately portrays KS pathogenesis still does not exist.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Factors
  • Cell Culture Techniques
  • Disease Models, Animal
  • Genes, Viral
  • HIV-1
  • Herpesvirus 8, Human / genetics
  • Humans
  • Sarcoma, Kaposi / etiology*
  • Sarcoma, Kaposi / pathology
  • Sarcoma, Kaposi / virology


  • Biological Factors