Disruption of circadian coordination accelerates malignant growth in mice

Pathol Biol (Paris). 2003 Jun;51(4):216-9. doi: 10.1016/s0369-8114(03)00034-8.


An animal model (mice B6D2F1) was developed to study the consequence of suprachiasmatic nuclei (SCN) destruction on tumor growth. SCN destruction abolished the rest-activity and body temperature rhythms and markedly altered the rhythms in serum corticosterone concentration and lymphocyte count. Tumor growth was faster in mice with lesioned SCN than in controls for both tumor models studied, Glasgow osteosarcoma (GOS) and pancreatic adenocarcinoma (P03). This shows that disruption of circadian coordination accelerates malignant growth in mice, suggesting that the host circadian clock controls tumor progression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / pathology*
  • Animals
  • Body Temperature Regulation
  • Bone Neoplasms / pathology*
  • Cell Division
  • Cell Line, Tumor / transplantation
  • Circadian Rhythm*
  • Corticosterone / metabolism
  • Disease Progression
  • Male
  • Mice
  • Osteosarcoma / pathology*
  • Pancreatic Neoplasms / pathology*
  • Suprachiasmatic Nucleus / injuries
  • Suprachiasmatic Nucleus / physiopathology


  • Corticosterone