Olanzapine for intractable nausea in palliative care patients

J Palliat Med. 2003 Apr;6(2):251-5. doi: 10.1089/109662103764978506.


Nausea is a common problem among palliative care patients, which is often undertreated. Olanzapine, an atypical antipsychotic, possesses a unique neurotransmitter binding profile that is similar to methotrimeprazine, an anti-emetic widely used in Europe for recalcitrant nausea. We report a case series of six patients who suffered nausea which was resistant to initial treatment with traditional antiemetics; each patient exhibited marked improvement when treated with olanzapine.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antiemetics / therapeutic use*
  • Benzodiazepines
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nausea / drug therapy*
  • Olanzapine
  • Palliative Care*
  • Pirenzepine / analogs & derivatives*
  • Pirenzepine / therapeutic use*
  • Treatment Outcome
  • United States


  • Antiemetics
  • Benzodiazepines
  • Pirenzepine
  • Olanzapine