Skew in CG content near the transcription start site in Arabidopsis thaliana

Bioinformatics. 2003:19 Suppl 1:i313-4. doi: 10.1093/bioinformatics/btg1043.

Abstract

We have discovered a novel statistical feature of Arabidopsis thaliana genome that remarkably correlates with a position of transcription start site--CG skew peak. We hypothesize that the phenomenon can be explained by the higher mutability of unprotected cytosines.

MeSH terms

  • Arabidopsis / genetics*
  • Base Composition
  • Cytosine*
  • DNA Mutational Analysis
  • Genetic Variation
  • Genome, Plant
  • Guanine*
  • Sequence Alignment / methods*
  • Sequence Analysis, DNA / methods*
  • Transcription Initiation Site*
  • Transcription, Genetic / genetics*

Substances

  • Guanine
  • Cytosine