Plasma adiponectin increases postprandially in obese, but not in lean, subjects

Obes Res. 2003 Jul;11(7):839-44. doi: 10.1038/oby.2003.115.


Objective: We investigated the acute responses of plasma adiponectin levels to a test meal in lean and obese subjects.

Research methods and procedures: We studied 13 lean and 11 obese subjects after a 10-hour overnight fast. Glucose, insulin, and adiponectin concentrations were measured at baseline and 15, 30, 60, 120, and 180 minutes after a fixed breakfast.

Results: At baseline, fasting adiponectin concentrations were lower in the obese group vs. the lean group [mean (95% confidence interval): 2.9 (2.1 to 4.1) microg/mL vs. 8.6 (6.5 to 11.3) microg/mL], but rose 4-fold postprandially in the obese group, reaching a peak at 60 minutes [baseline: 2.9 (2.1 to 4.1) microg/mL vs. 60 minutes: 12.1 (8.5 to 17.4) microg/mL; p< 0.0001] and remaining elevated for the remainder of the study. There were no postprandial changes in plasma adiponectin concentrations in lean subjects.

Discussion: This increase of adiponectin concentrations in obese individuals might have important beneficial effects on postprandial glucose and lipid metabolism and might be viewed as a mechanism for maintaining normal glucose tolerance in those who are obese and insulin resistant.

MeSH terms

  • Adiponectin
  • Adult
  • Blood Glucose / metabolism
  • Body Mass Index
  • Fasting
  • Female
  • Food*
  • Homeostasis
  • Humans
  • Insulin / blood
  • Insulin Resistance
  • Intercellular Signaling Peptides and Proteins*
  • Kinetics
  • Male
  • Obesity / blood*
  • Proteins / analysis*


  • Adiponectin
  • Blood Glucose
  • Insulin
  • Intercellular Signaling Peptides and Proteins
  • Proteins