Complement: structure, functions, evolution, and viral molecular mimicry

Immunol Res. 2003;27(2-3):367-86. doi: 10.1385/IR:27:2-3:367.


The complement (C') system has long been recognized as an important mediator of innate immune defense and inflammation. In recent years there is increasing evidence suggesting that complement components may also participate in non-inflammatory and developmental processes. Here we review our current work on the structural-functional aspects of C3-ligand interactions and the rational design of small-sized complement inhibitors. We present a novel, proteomics-based, approach to studying protein-protein interactions within the C' system and discuss our progress in the study of viral immune evasion strategies. Furthermore we discuss the involvement of complement proteins in organ regeneration and hematopoietic development.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Complement C3 / chemistry
  • Complement C3 / physiology
  • Complement Inactivator Proteins / chemistry
  • Complement Inactivator Proteins / physiology
  • Complement System Proteins*
  • Evolution, Molecular*
  • Humans
  • Ligands
  • Molecular Mimicry / immunology*
  • Structure-Activity Relationship
  • Virus Diseases / immunology


  • Complement C3
  • Complement Inactivator Proteins
  • Ligands
  • Complement System Proteins