The pathogenesis and diagnosis of foot-and-mouth disease

S Alexandersen; Z Zhang; A I Donaldson; A J M Garland

doi:10.1016/s0021-9975(03)00041-0

The pathogenesis and diagnosis of foot-and-mouth disease

J Comp Pathol. 2003 Jul;129(1):1-36. doi: 10.1016/s0021-9975(03)00041-0.

Authors

S Alexandersen¹, Z Zhang, A I Donaldson, A J M Garland

Affiliation

¹ Pirbright Laboratory, Institute for Animal Health, Ash Road, Pirbright, Woking, Surrey GU24 ONF, UK.

PMID: 12859905
DOI: 10.1016/s0021-9975(03)00041-0

Abstract

The pathogenesis of foot-and-mouth disease (FMD) is reviewed, taking account of knowledge gained from field and experimental studies and embracing investigations at the level of the virus, the cell, the organ, the whole animal and the herd or flock. The review also addresses the immune response and the carrier state in FMD. Progress made in understanding the pathogenesis of the disease is highlighted in relation to developments in diagnosis and methods of control.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Carrier State
Foot-and-Mouth Disease / diagnosis*
Foot-and-Mouth Disease / etiology*
Foot-and-Mouth Disease / immunology
Foot-and-Mouth Disease Virus / immunology
Foot-and-Mouth Disease Virus / pathogenicity*