The pathogenesis and diagnosis of foot-and-mouth disease

J Comp Pathol. 2003 Jul;129(1):1-36. doi: 10.1016/s0021-9975(03)00041-0.


The pathogenesis of foot-and-mouth disease (FMD) is reviewed, taking account of knowledge gained from field and experimental studies and embracing investigations at the level of the virus, the cell, the organ, the whole animal and the herd or flock. The review also addresses the immune response and the carrier state in FMD. Progress made in understanding the pathogenesis of the disease is highlighted in relation to developments in diagnosis and methods of control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier State
  • Foot-and-Mouth Disease / diagnosis*
  • Foot-and-Mouth Disease / etiology*
  • Foot-and-Mouth Disease / immunology
  • Foot-and-Mouth Disease Virus / immunology
  • Foot-and-Mouth Disease Virus / pathogenicity*