Causation of chronic lymphocytic leukemia--insights from familial disease

Leuk Res. 2003 Oct;27(10):871-6. doi: 10.1016/s0145-2126(03)00023-7.


In Western countries B-cell chronic lymphocytic leukemia (CLL) is the most common form of leukemia. Evidence from epidemiological studies and family studies strongly supports the notion that a subset of CLL involves inherited susceptibility. Identification of genes predisposing to CLL should be useful for diagnosis and treatment, as well as serving as a model for B-cell tumorigenesis in general. Here, we review the current status of knowledge about inherited susceptibility to CLL.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Family Health
  • Genetic Predisposition to Disease*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / epidemiology
  • Leukemia, Lymphocytic, Chronic, B-Cell / etiology
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*